general transcription factor IIIC subunit 6
External References:
Entrez ID: 112495
NCBI Description of GTF3C6
RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.[supplied by OMIM, Mar 2008]
Genome Assembly: GRCh37.p13/hg19
in ESCC tumor or normal tissues of 94 ESCC patients
| SNP | Location | Region | Allele | Effect size | P-value | FDR | Mapped gene(s) | Tissue | Action | Study |
|---|---|---|---|---|---|---|---|---|---|---|
| rs781499 | 6:111260923 | 6q21 | A/G | -0.19 | 2.40E-05 | 6.90E-03 | GTF3C6 | Adjacent normal tissue | eQTL boxplot | Chang J, et al. (PMID: 28548104), 2017 |
