cyclin dependent kinase 19
External References:
Entrez ID: 23097
NCBI Description of CDK19
This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Genome Assembly: GRCh37.p13/hg19
in 1,006 ESCC patients
| SNP | Location | Region | Allele | P-value | Model | Functional class | Mapped gene(s) | Study |
|---|---|---|---|---|---|---|---|---|
| rs150125841 | 6:111019832 | 6q21 | T/G | 2.80E-08 | Additive | intronic | CDK19 | Chang J, et al. (PMID: 28548104), 2017 |
| rs143508528 | 6:111125341 | 6q21 | A/G | 9.46E-07 | Additive | intronic | CDK19 | Chang J, et al. (PMID: 28548104), 2017 |
| rs145640901 | 6:111125829 | 6q21 | G/T | 9.46E-07 | Additive | intronic | CDK19 | Chang J, et al. (PMID: 28548104), 2017 |