ADH1A

alcohol dehydrogenase 1A (class I), alpha polypeptide

External References:

Entrez ID: 124


NCBI Description of ADH1A

This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence. [provided by RefSeq, Nov 2010]


Genome Assembly: GRCh37.p13/hg19

Association with gene expression

in ESCC tumor or normal tissues of 94 ESCC patients

SNPLocationRegionAlleleEffect sizeP-valueFDRMapped
gene(s)
TissueActionStudy
rs38118024:1002442214q23A/C,G-0.782.19E-056.44E-03ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs28512994:1002596184q23T/C-0.878.37E-051.78E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs775956424:1002692784q23T/TTTTTA-0.791.28E-042.40E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs40939244:1002770104q23T/C-0.751.37E-042.54E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs12380154:1002811344q23T/C-0.751.37E-042.54E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs31331554:1002272124q23C/G0.751.42E-042.61E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17898824:1002350534q23A/G0.751.42E-042.61E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934574:1002367624q23C/T0.751.42E-042.61E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs41475364:1002391124q23A/C0.751.42E-042.61E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17898924:1002506584q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs11544334:1002537084q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs12299784:1002561994q23T/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16620314:1002567934q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16127354:1002580074q23T/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17898984:1002583364q23A/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs14424794:1002586754q23T/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs14424804:1002586814q23A/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899004:1002587174q23A/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs14424814:1002590474q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16620604:1002598414q23T/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899024:1002601714q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934764:1002602744q23T/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16620594:1002603784q23A/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs6984:1002607894q23T/A,C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs22987554:1002610384q23C/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs31140484:1002612164q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934714:1002619524q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899034:1002620414q23C/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16620584:1002627594q23T/A,C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934774:1002630624q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899064:1002632194q23T/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs9040934:1002632474q23T/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs9040944:1002632524q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs9040954:1002633834q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16620574:1002634144q23T/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs9040964:1002635844q23T/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899104:1002637154q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934804:1002637624q23G/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899114:1002637784q23T/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934814:1002638344q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899124:1002639424q23C/A,T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934824:1002639654q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16314604:1002646204q23G/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934834:1002649464q23T/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934244:1002652364q23C/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16254394:1002653254q23C/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899134:1002653484q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs623072974:1002655154q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs623072984:1002655504q23C/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899144:1002656034q23G/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs793068774:1002658294q23T/TAACTC-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934254:1002661124q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934264:1002663304q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16620534:1002665834q23A/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16620524:1002666354q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899164:1002666964q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934274:1002668274q23T/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934284:1002669314q23A/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899174:1002671644q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16620514:1002672394q23C/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899194:1002677194q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934314:1002680494q23T/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs667644044:1002708194q23C/CTG-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs359207084:1002710094q23TA/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16292704:1002713064q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16620494:1002718494q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs106349184:1002733724q23G/GACTTA-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899244:1002742864q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16298384:1002748964q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs25844534:1002753054q23C/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs3682807454:1002756294q23G/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17899254:1002757454q23T/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934694:1002759024q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs114998264:1002769364q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs24539804:1002774374q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs3977181434:1002780114q23G/GAGA-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs9809724:1002792474q23C/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16934704:1002794894q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs16620394:1002796844q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs28513004:1002798244q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs12345844:1002800414q23G/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs12298584:1002816344q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs12298574:1002817084q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs12298564:1002819054q23G/C-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs12298554:1002822954q23A/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs12298544:1002825504q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs12298514:1002838254q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs11544354:1002851484q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs11544384:1002858874q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs11544394:1002862334q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs11544404:1002864474q23G/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs12299734:1002871784q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs11544424:1002878494q23C/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs11544444:1002880894q23T/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs11544454:1002885214q23T/G-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs709583044:1002887814q23AGAAT/A-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs11544474:1002890344q23G/T-0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs17898964:1002569844q23G/A0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs2834084:1002771144q23G/T0.731.49E-042.69E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs2834154:1002706074q23C/T0.681.84E-043.12E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs21656704:1002860854q23G/A-0.832.58E-043.97E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017
rs3977874254:1002439024q23G/GA0.673.54E-045.00E-02ADH1AAdjacent normal tissueeQTL boxplotChang J, et al. (PMID: 28548104), 2017