alcohol dehydrogenase 1B (class I), beta polypeptide
External References:
Entrez ID: 125
NCBI Description of ADH1B
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Genome Assembly: GRCh37.p13/hg19
in 2,022 ESCC cases and 2,039 controls
| SNP | Location | Region | Allele | MAF | P-value | OR(95% CI) | Functional class | Mapped gene(s) | Study |
|---|---|---|---|---|---|---|---|---|---|
| rs1042026 | 4:100228466 | 4q23 | T/C | 0.23 | 1.11E-15 | 1.49 (1.35-1.64) | UTR3 | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs12507573 | 4:100226324 | 4q23 | C/A | 0.13 | 5.00E-10 | 1.47 (1.3-1.66) | intergenic | LOC100507053(dist=3811), ADH1B(dist=1220) | Wu C, et al. (PMID: 21642993), 2011 |
| rs17033 | 4:100228945 | 4q23 | T/C | 0.11 | 1.84E-09 | 1.48 (1.31-1.69) | UTR3 | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs2075633 | 4:100238998 | 4q23 | T/C | 0.21 | 6.20E-09 | 1.36 (1.23-1.51) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs11730075 | 4:100237833 | 4q23 | A/G | 0.21 | 7.14E-09 | 1.36 (1.22-1.51) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs2066701 | 4:100238413 | 4q23 | G/A | 0.21 | 7.14E-09 | 1.36 (1.22-1.51) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs2070898 | 4:100243297 | 4q23 | G/A | 0.22 | 7.74E-09 | 1.36 (1.22-1.5) | upstream | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs10033960 | 4:100231342 | 4q23 | G/A | 0.21 | 1.03E-08 | 1.35 (1.22-1.5) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs10005290 | 4:100229410 | 4q23 | A/C | 0.21 | 1.14E-08 | 1.35 (1.22-1.5) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs35333426 | 4:100224036 | 4q23 | G/A | 0.21 | 1.36E-08 | 1.35 (1.22-1.5) | intergenic | LOC100507053(dist=1523), ADH1B(dist=3508) | Wu C, et al. (PMID: 21642993), 2011 |
| rs13106840 | 4:100225459 | 4q23 | G/A | 0.21 | 1.53E-08 | 1.35 (1.22-1.5) | intergenic | LOC100507053(dist=2946), ADH1B(dist=2085) | Wu C, et al. (PMID: 21642993), 2011 |
| rs2070897 | 4:100243310 | 4q23 | G/A | 0.19 | 3.52E-08 | 1.36 (1.22-1.51) | upstream | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs2173201 | 4:100250970 | 4q23 | C/A | 0.26 | 5.07E-08 | 1.31 (1.19-1.44) | intergenic | ADH1B(dist=8371), ADH1C(dist=6679) | Wu C, et al. (PMID: 21642993), 2011 |
| rs1159918 | 4:100243009 | 4q23 | A/C | 0.19 | 5.58E-08 | 1.35 (1.21-1.5) | upstream | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs1229984 | 4:100239319 | 4q23 | T/C | 0.28 | 5.71E-08 | 1.31 (1.19-1.44) | exonic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs6810842 | 4:100243445 | 4q23 | T/G | 0.19 | 6.77E-08 | 1.35 (1.21-1.5) | upstream | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs12498658 | 4:100237821 | 4q23 | G/A | 0.1 | 2.25E-07 | 1.44 (1.25-1.65) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs28914793 | 4:100227327 | 4q23 | A/T | 0.1 | 2.94E-07 | 1.43 (1.25-1.64) | downstream | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs28914783 | 4:100231602 | 4q23 | C/T | 0.1 | 2.94E-07 | 1.43 (1.25-1.64) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs3811802 | 4:100244221 | 4q23 | A/C,G | 0.1 | 3.66E-07 | 1.43 (1.24-1.63) | intergenic | ADH1B(dist=1622), ADH1C(dist=13428) | Wu C, et al. (PMID: 21642993), 2011 |
| rs28913921 | 4:100238106 | 4q23 | AG/A | 0.08 | 1.10E-06 | 1.47 (1.26-1.71) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs111797757 | 4:100223957 | 4q23 | A/C | 0.08 | 1.19E-06 | 1.46 (1.25-1.69) | intergenic | LOC100507053(dist=1444), ADH1B(dist=3587) | Wu C, et al. (PMID: 21642993), 2011 |
| rs28914794 | 4:100227288 | 4q23 | G/C | 0.08 | 1.19E-06 | 1.46 (1.25-1.69) | downstream | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs28914770 | 4:100233892 | 4q23 | C/T | 0.08 | 1.19E-06 | 1.46 (1.25-1.69) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs77928255 | 4:100227820 | 4q23 | CCT/C | 0.08 | 1.51E-06 | 1.45 (1.25-1.69) | UTR3 | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs28914775 | 4:100233126 | 4q23 | C/T | 0.08 | 1.51E-06 | 1.45 (1.25-1.69) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs2213042 | 4:100249210 | 4q23 | T/C | 0.25 | 1.66E-06 | 1.28 (1.16-1.42) | intergenic | ADH1B(dist=6611), ADH1C(dist=8439) | Wu C, et al. (PMID: 21642993), 2011 |
| rs3840297 | 4:100239719 | 4q23 | CAT/C | 0.08 | 1.73E-06 | 1.45 (1.24-1.69) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs58223772 | 4:100256165 | 4q23 | TC/T | 0.25 | 1.87E-06 | 1.28 (1.16-1.41) | intergenic | ADH1B(dist=13565), ADH1C(dist=1484) | Wu C, et al. (PMID: 21642993), 2011 |
| rs372446680 | 4:100237485 | 4q23 | GTTC/G | 0.08 | 1.91E-06 | 1.45 (1.25-1.7) | intronic | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs73832758 | 4:100226777 | 4q23 | A/C | 0.08 | 2.30E-06 | 1.44 (1.24-1.68) | downstream | ADH1B | Wu C, et al. (PMID: 21642993), 2011 |
| rs56948765 | 4:100225336 | 4q23 | G/A | 0.08 | 3.38E-06 | 1.43 (1.23-1.66) | intergenic | LOC100507053(dist=2823), ADH1B(dist=2208) | Wu C, et al. (PMID: 21642993), 2011 |
MAF: minor allele frequency in controls