alcohol dehydrogenase 1C (class I), gamma polypeptide
External References:
Entrez ID: 126
NCBI Description of ADH1C
This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
Genome Assembly: GRCh37.p13/hg19
in 2,022 ESCC cases and 2,039 controls
| SNP | Location | Region | Allele | MAF | P-value | OR(95% CI) | Functional class | Mapped gene(s) | Study |
|---|---|---|---|---|---|---|---|---|---|
| rs2173201 | 4:100250970 | 4q23 | C/A | 0.26 | 5.07E-08 | 1.31 (1.19-1.44) | intergenic | ADH1B(dist=8371), ADH1C(dist=6679) | Wu C, et al. (PMID: 21642993), 2011 |
| rs1614972 | 4:100258155 | 4q23 | C/T | 0.26 | 6.28E-08 | 1.31 (1.19-1.44) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs200172585 | 4:100259549 | 4q23 | TTTTC/T | 0.29 | 2.85E-07 | 1.29 (1.17-1.42) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs3811802 | 4:100244221 | 4q23 | A/C,G | 0.1 | 3.66E-07 | 1.43 (1.24-1.63) | intergenic | ADH1B(dist=1622), ADH1C(dist=13428) | Wu C, et al. (PMID: 21642993), 2011 |
| rs17028973 | 4:100322786 | 4q23 | T/C | 0.34 | 6.04E-07 | 1.26 (1.15-1.38) | intergenic | ADH1C(dist=48584), ADH7(dist=10632) | Wu C, et al. (PMID: 21642993), 2011 |
| rs1302808 | 4:100291120 | 4q23 | C/A | 0.07 | 7.04E-07 | 1.51 (1.28-1.77) | intergenic | ADH1C(dist=16918), ADH7(dist=42298) | Wu C, et al. (PMID: 21642993), 2011 |
| rs11499824 | 4:100274983 | 4q23 | C/T | 0.25 | 9.81E-07 | 1.29 (1.16-1.42) | upstream | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs1789898 | 4:100258336 | 4q23 | A/C | 0.09 | 1.13E-06 | 1.43 (1.24-1.65) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs12639833 | 4:100267372 | 4q23 | C/T | 0.25 | 1.15E-06 | 1.28 (1.16-1.42) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs1154435 | 4:100285148 | 4q23 | G/A | 0.09 | 1.18E-06 | 1.43 (1.24-1.65) | intergenic | ADH1C(dist=10946), ADH7(dist=48270) | Wu C, et al. (PMID: 21642993), 2011 |
| rs3846449 | 4:100259126 | 4q23 | T/C | 0.25 | 1.46E-06 | 1.28 (1.16-1.42) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs2009181 | 4:100262547 | 4q23 | A/G | 0.25 | 1.46E-06 | 1.28 (1.16-1.42) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs2241894 | 4:100266133 | 4q23 | T/C | 0.25 | 1.46E-06 | 1.28 (1.16-1.42) | exonic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs12649804 | 4:100281078 | 4q23 | T/C | 0.25 | 1.52E-06 | 1.28 (1.16-1.42) | intergenic | ADH1C(dist=6876), ADH7(dist=52340) | Wu C, et al. (PMID: 21642993), 2011 |
| rs2213042 | 4:100249210 | 4q23 | T/C | 0.25 | 1.66E-06 | 1.28 (1.16-1.42) | intergenic | ADH1B(dist=6611), ADH1C(dist=8439) | Wu C, et al. (PMID: 21642993), 2011 |
| rs58223772 | 4:100256165 | 4q23 | TC/T | 0.25 | 1.87E-06 | 1.28 (1.16-1.41) | intergenic | ADH1B(dist=13565), ADH1C(dist=1484) | Wu C, et al. (PMID: 21642993), 2011 |
| rs10006545 | 4:100277432 | 4q23 | G/A | 0.24 | 1.93E-06 | 1.28 (1.16-1.41) | intergenic | ADH1C(dist=3230), ADH7(dist=55986) | Wu C, et al. (PMID: 21642993), 2011 |
| rs10031168 | 4:100281893 | 4q23 | T/C | 0.24 | 1.93E-06 | 1.28 (1.16-1.41) | intergenic | ADH1C(dist=7691), ADH7(dist=51525) | Wu C, et al. (PMID: 21642993), 2011 |
| rs6846835 | 4:100272147 | 4q23 | T/C | 0.24 | 2.10E-06 | 1.28 (1.16-1.41) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs11936869 | 4:100273173 | 4q23 | C/G | 0.24 | 2.10E-06 | 1.28 (1.16-1.41) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs3762896 | 4:100268131 | 4q23 | C/T | 0.24 | 2.32E-06 | 1.28 (1.15-1.41) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs4147542 | 4:100268553 | 4q23 | T/C | 0.24 | 2.32E-06 | 1.28 (1.15-1.41) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs2298753 | 4:100257907 | 4q23 | T/C | 0.07 | 2.75E-06 | 1.47 (1.25-1.73) | UTR3 | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs4147541 | 4:100274157 | 4q23 | G/C | 0.25 | 3.49E-06 | 1.27 (1.15-1.41) | UTR5 | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs2298755 | 4:100261038 | 4q23 | C/G | 0.09 | 3.63E-06 | 1.41 (1.22-1.62) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs1789911 | 4:100263778 | 4q23 | T/C | 0.09 | 3.63E-06 | 1.41 (1.22-1.62) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs1693476 | 4:100260274 | 4q23 | T/C | 0.09 | 4.05E-06 | 1.4 (1.22-1.62) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs1789903 | 4:100262041 | 4q23 | C/G | 0.09 | 4.40E-06 | 1.4 (1.21-1.62) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs1693424 | 4:100265236 | 4q23 | C/G | 0.09 | 5.22E-06 | 1.4 (1.21-1.62) | intronic | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs1789896 | 4:100256984 | 4q23 | G/A | 0.09 | 5.41E-06 | 1.39 (1.21-1.61) | downstream | ADH1C | Wu C, et al. (PMID: 21642993), 2011 |
| rs1442493 | 4:100321365 | 4q23 | G/A,C | 0.35 | 7.34E-06 | 1.23 (1.12-1.35) | intergenic | ADH1C(dist=47163), ADH7(dist=12053) | Wu C, et al. (PMID: 21642993), 2011 |
| rs12644388 | 4:100290340 | 4q23 | A/T | 0.26 | 8.90E-06 | 1.25 (1.13-1.38) | intergenic | ADH1C(dist=16138), ADH7(dist=43078) | Wu C, et al. (PMID: 21642993), 2011 |
MAF: minor allele frequency in controls